Neuromuscular Blockers PHYSIOLOGY OF NEUROMUSCULAR TRANSMISSION Anatomy of the Neuromuscular Junction
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the structure was established by King in 1935, however, one of the nitrogen groups was later found to be tertiary a synthetic analogue, metocurine, was developed several years later with 3x the potency of dTC gallamine, another of the series, was synthesised about 1950 NB: in 1954 Beecher & Todd published their multi-institutional report which showed a 6-fold increase in mortality with the use of muscle relaxants
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